DirectMeds vs Fridays: NAD+ Therapy Compared
DirectMeds starts at $99 first month (500mg) and offers injection, while Fridays starts at $179/mo (billed quarterly) with injection, nasal spray & oral liposomal. Below we line them up on price, delivery formats, dosing, shipping, and overall value so you can see which prescription NAD+ provider fits you best.
DirectMeds
Save $100 first month — 500mg from $99, then $199. 250,000+ served. No subscription.
Visit DirectMeds →
Fridays
NAD+ from $179/mo (billed quarterly). Injection, nasal spray, or oral liposomal.
Visit Fridays →| Feature | DirectMeds | Fridays |
|---|---|---|
| Editorial score | 9.64 / 10 | 9.43 / 10 |
| Starting price | $99 first month (500mg) | $179/mo (billed quarterly) |
| Renewal / ongoing | $199 (500mg) / $249 (1000mg) | Nasal & oral $229/mo |
| Delivery formats | Injection | Injection, nasal spray & oral liposomal |
| Dose strengths | 500mg & 1000mg | Oral 50/100/150mg daily; injection 3×/week |
| Shipping | Free 1–2 day | Medication included |
| Membership / fees | None — no subscription | None |
| Guarantee | Satisfaction guarantee | — |
| Best for | People who want exact upfront pricing and no forced subscription, reordering on their own schedule | People wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery |
Where DirectMeds stands out
- + Lower entry price — $99 first month (500mg)
- + Backed by a satisfaction guarantee
- + Higher editorial score (9.64 vs 9.43)
Where Fridays stands out
- + More delivery formats — injection, nasal spray & oral liposomal
Pros & cons, side by side
DirectMeds
Pros
- + $100 off first month on the 500mg plan
- + Exact pricing shown upfront for both 500mg and 1000mg
- + No forced subscription — reorder manually when you want
- + 1:1 medical support with provider review within 24 hours
- + Free 1–2 day shipping included
Cons
- − Injection-only — no nasal or oral option
- − 1000mg plan renews at $249/mo
Fridays
Pros
- + One of the few providers offering injection, nasal spray, AND oral liposomal NAD+
- + Personalized protocol for your goals
- + Established trusted brand
Cons
- − Billed quarterly rather than month-to-month
- − Not available in all states
The verdict: DirectMeds vs Fridays
In our editorial ranking, DirectMeds places higher (#5 vs #8), making it the default pick for most readers — it's best for people who want exact upfront pricing and no forced subscription, reordering on their own schedule. That said, Fridays is the stronger choice for people wanting personalized NAD+ with a choice of injection, nasal spray, or oral delivery. Both are prescription NAD+ services, so the right answer depends on the delivery format and price structure that match how you want to start.
More head-to-head comparisons
Pricing and product details were verified against each provider's official pages and may change — always confirm current terms on the provider's site. Rx required; a licensed provider determines whether NAD+ therapy is appropriate for you. We may earn a commission from links on this page, which never affects our rankings.